When Creating a PDF file, you must ensure that the PDF is accessible.

Making PDFs from MS Word Documents

Since most PDFs are created from MS Word documents, ensure that the Word document is created in an accessible manner so that when converted to PDF the resulting document will be accessible. Information on creating accessible PDFs (and accessible Microsoft Office documents) is available on Cal Poly's Accessibility Web site (see the Electronic Documents sub-heading).

Adobe has created an excellent two page quick reference for Preparing Microsoft Word Documents to Create Accessible PDF Files, and Converting Microsoft Word Documents to Accessible PDF Files with Adobe Acrobat.